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Manchester United kick off the weekend action at home to Aston Villa, looking to bounce back from their midweek Carabao Cup defeat.
A thrilling finale against West Ham last time out in the league was quickly forgotten three days later when the Hammers went to Old Trafford and won, and Ole Gunnar Solskjaer will know another home defeat could prove costly.
With Premier League title rivals Man City and Chelsea facing off against each other at the same time, three points against Villa (12.30pm kick off) could see United move clear at the top of the table.
Solskjaer has been boosted by the return to fitness of Edinson Cavani, who is back in the United squad, while Cristiano Ronaldo again starts up front, with Fred and Scott McTominay in midfield.
United XI: De Gea, Wan-Bissaka, Shaw, Maguire, Varane, Fred, McTominay, Fernandes, Pogba, Greenwood, Ronaldo.
Subs: Heaton, Lindelof, Dalot, Lingard, Matic, Van de Beek, Sancho, Martial, Cavani.
